An investigation on wear behavior of UHMWPE/carbide composites at elevated temperatures

Ultra-high molecular weight polyethylene (UHMWPE) is extensively used in frictional applications due to its advanced wear resistance. This advanced polymer is reinforced with hard particulate fillers for further developments against wear conditions. Since elevated temperatures prevail in the service conditions, wear behavior of UHMWPE composites is an important issue for the engineering applications. In the present work, UHMWPE-based composites including silicon carbide (SiC) fillers were fabricated in a compression molding chamber. In the specimen preparation stage, molding pressure, filler amount, and filler particle size were varied to investigate the influence of these variables. Upon deciding the optimum parameters from the wear tests conducted at room temperature, the wear experiments were repeated for the optimum specimen at elevated temperatures, such as 40 and 60°C. According to the results, the wear behavior of the SiC/UHMWPE composites is heavily changed by the effect of elevated temperature. Adhesive effect is pronounced at elevated temperatures while the wear characteristics possess the abrasive effect in the sliding path. In addition, the composites exhibit an accelerated material loss as temperature increases during the frictional system.     

Production of two-material micro-assemblies by two-component powder injection molding and sinter-joining

In the field of micro-technology the production of metallic and ceramic micro-components by powder injection molding (PIM) has become a more and more established fabrication method. But in order to fulfill the demand for more complex-shaped high-precision micro-components further development work has to be performed. This is especially true if more efficient production routes for multi-component-micro-assemblies consisting of different materials or sub-components are envisaged. To meet these challenges, investigations are performed to realize and to establish two primary shape micro-processes. These are two-component micro-injection molding (2C-MicroPIM) and sinter-joining. The realization of these technologies will lead to a markedly reduction of the efforts for handling, adjustment, and assembling of metallic and ceramic micro-assemblies. Furthermore, an increased integration level and functionality can be yielded. For an effective transfer of scientific results to industrial applications the whole process chain must be considered, from development and construction of the tooling as well as of the components to the quality assurance and determination of the properties of the assemblies after sintering. These primary shape processes shall enable the mutual processing of different materials within the fabrication process, so avoiding separate mounting or assembling steps. Additionally fixed and loose junctions between at least two components shall be realized. The progress in research and development will be demonstrated especially by the implementation of shaft-to-collar connections between micro-gearwheels and corresponding shafts. Regarding two-component micro-injection molding, the tool construction for shaft-to-collar connections will be presented as well as first experimental results on the properties of selected ceramic powders and feedstocks for the special requirements of the 2C-MicroPIM process. With the assembly step being performed outside the injection molding tool before sinter-joining different parts and geometries can be combined quite easily. The presented article gives an overview on the concept and on preliminary testing results for the fabrication of a shaft-to-collar-connection. Additionally, a solution for an automated assembly of a shaft and a toothed wheel outside the injection molding tool is presented.     

Stiction issues and actuation of RF LIGA-MEMS variable capacitors

High aspect ratio variable capacitors have been fabricated using deep X-ray lithography and electroplating. Stiction phenomena applicable to high aspect ratio devices are presented, including the conditions for stiction to occur and the critical dimensions of structures. Actuation tests at 3 GHz are also presented and show a maximum capacitance of 0.86 pF with no actuation voltage and a minimum capacitance of 0.70 pF with an actuation voltage of 20 V just before pull-in, which gives a tuning range of 1.23:1. Corresponding Q-factor values are 49.3 and 70.8 respectively. After pull-in, the measured capacitance is 0.61 pF, corresponding to a tuning range of 1.41:1, with a maximum Q-factor of 102.9.     

Interactive survival analysis with the OCDM system: From development to application

Medical data mining is currently actively pursued in computer science and statistical research but not in medical practice. The reasons therefore lie in the difficulties of handling and statistically analyzing medical data. We have developed a system that allows practitioners in the field to interactively analyze their data without assistance of statisticians or data mining experts. In the course of this paper we will introduce data mining of medical data and show how this can be achieved for survival data. We will demonstrate how to solve common problems of interactive survival analysis by presenting the Online Clinical Data Mining (OCDM) system. Thereby the main focus is on similarity based queries, a new method to select similar cases based on their covariables and the influence of these on their survival.     

Das datenschutzrechtliche Vollzugsdefizit im Bereich der Telemedien — ein Schreckensbericht

Zusammenfassung  Die Autoren untersuchen das datenschutzrechtliche Vollzugsdefizit im Anwendungsbereich des Telemediengesetzes. Ihr Ergebnis ist, dass das Ausma? des datenschutzrechtlichen Vollzugsdefizits der von au?en zu überprüfenden datenschutzrechtlichen Pflichten der Anbieter „erschreckend“ ist. Nur einem ganz geringen Teil der Anbieter gelingt es, sich rechtskonform zu verhalten. Prof. Dr. Jürgen Kühling Inhaber eines Lehrstuhls für ?ffentliches Recht an der Universit?t Regensburg. Anastasios Sivridis wissenschaftlicher Mitarbeiter und Doktorand am Lehrstuhl Prof. Kühling. Mathis Schwuchow studentische Hilfskraft am Lehrstuhl Prof. Kühling. Thorben Burghardt wissenschaftlicher Mitarbeiter und Doktorand am Lehrstuhl für Systeme der Informationsverwaltung (TH Karlsruhe).     

Tracing pathway activities with kinase inhibitors and reverse phase protein arrays

Controlling aberrant protein kinase activity is a promising strategy for a variety of diseases, particularly cancer. Hence, the development of kinase inhibitors is currently a focal point for pharmaceutical research. In this study we utilize a chip-based reverse phase protein array (RPA) platform for profiling of kinase inhibitors in cell-based assays. In combination with the planar wave-guide technology the assay system has an absolute LOD down to the low zeptomole range. A431 cell lysates were analyzed for the activation state of key effectors in the epidermal growth factor (EGF) and insulin signaling pathways to validate this model for compound screening. A microtiter-plate format for growing, treating, and lysing cells was shown to be suitable for this approach, establishing the value of the technology as a screening tool for characterization of large numbers of kinase inhibitors against a wide variety of cellular signaling pathways. Moreover, the reverse array format allows rapid development of site-specific phosphorylation assays, since in contrast to ELISA type systems only a single antigen-specific antibody is required.     

Quantitative mass spectrometry to investigate epidermal growth factor receptor phosphorylation dynamics

Identifying proteins of signaling networks has received much attention, because an array of biological processes are entirely dependent on protein cross-talk and protein-protein interactions. Protein posttranslational modifications (PTM) add an additional layer of complexity, resulting in complex signaling networks. Of particular interest to our working group are the signaling networks of epidermal growth factor (EGF) receptor, a transmembrane receptor tyrosine kinase involved in various cellular processes, including cell proliferation, differentiation, and survival. Ligand binding to the N-terminal residue of the extracellular domain of EGF receptor induces conformational changes, dimerization, and (auto)-phosphorylation of intracellular tyrosine residues. In addition, activated EGF receptor may positively affect survival pathways, and thus determines the pathways for tumor growth and progression. Notably, in many human malignancies exaggerated EGF receptor activities are commonly observed. An understanding of the mechanism that results in aberrant phosphorylation of EGF receptor tyrosine residues and derived signaling cascades is crucial for an understanding of molecular mechanisms in cancer development. Here, we summarize recent labeling methods and discuss the difficulties in quantitative MS-based phosphorylation assays to probe for receptor tyrosine kinase (RTK) activity. We also review recent advances in sample preparation to investigate membrane-bound RTKs, MS-based detection of phosphopeptides, and the diligent use of different quantitative methods for protein labeling.     

Mechanical theorem proving in projective geometry

We present an algorithm that is able to confirm projective incidence statements by carrying out calculations in the ring of all formal determinants (brackets) of a configuration. We will describe an implementation of this prover and present a series of examples treated by the prover, includingPappus' andDesargues' theorems, thesixteen point theorem, Saam's theorem, thebundle condition, theuniqueness of a harmonic point andPascal's theorem.     

Overcoming Anode Instability in Solid-State Batteries through Control of the Lithium Metal Microstructure

Enabling the lithium metal anode (LMA) in solid-state batteries (SSBs) is the key to developing high energy density battery technologies. However, maintaining a stable electrode–electrolyte interface presents a critical challenge to high cycling rate and prolonged cycle life. One such issue is the interfacial pore formation in LMA during stripping. To overcome this, either higher stack pressure or binary lithium alloy anodes are used. Herein, it is shown that fine-grained (d = 20 µm) polycrystalline LMA can avoid pore formation by exploiting the microstructural dependence of the creep rates. In a symmetric cell set-up, i.e., LiǀLi_6.25Al_0.25La₃Zr₂O₁₂(LLZO)ǀLi, fine-grained LMA achieves > 11.0 mAh cm⁻² compared to ≈ 3.6 mAh cm⁻² for coarse-grained LMA (d = 295 µm) at 0.1 mA cm⁻² and at moderate stress of 2.0 MPa. Smaller diffusion lengths (≈ 20 µm) and higher diffusivity pathway along dislocations (D_d ≈ 10⁻⁷ cm² s⁻¹), generated during cell fabrication, result in enhanced viscoplastic deformation in fine-grained polycrystalline LMA. The electrochemical performances corroborate well with estimated creep rates. Thus, microstructural control of LMA can significantly reduce the required stack pressure during stripping. These results are particularly relevant for “anode-free” SSBs wherein both the microstructure and the mechanical state of the lithium are critical parameters.